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Variant brain-derived neurotrophic factor (BDNF) (Met66) alters the intracellular trafficking and activity-dependent secretion of wild-type BDNF in neurosecretory cells and cortical neurons

RAF participated in the design of the study and drafting the manuscript, contributing in all review section

The skin slices were subsequently incubated overnight at 4C with the primary antibody (1:200)

While these findings highlight possible directions for future study, the mechanisms and broader implications remain areas of ongoing exploration

Sickle cell anemia is an inherited genetic disease that causes the formation of hemoglobin fibrils resulting in a loss in the cells ability to transport oxygen

(Figure 1) Patients with EHR demonstrated significant early initial HCC recurrence than the patients without EHR