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This is supported by Yu et al.s work demonstrating that baicalin induced apoptotic cell death in HepG2 and SMMC-7721 cells (HCC lines), which was accompanied by upregulation of Bax, downregulation of B-cell lymphoma-2 (Bcl-2), and cleavages of Caspase-9, Caspase-3, and poly (ADP-ribose) polymerase (PARP) (Yu et al., 2015)