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[8] Although not an absolute contraindication, patients with coronary artery disease or unstable angina should only use B-Complex injections containing niacinamide under physician supervision, since high-dose niacin supplements have been linked to arrhythmias in such patients

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High levels of vitamin B12 may suggest other issues, such as types of liver diseases, blood cancer or blood disorders, due to vitamin B12 levels rising in the disease process

Its primary function is to transfer a methyl group to nicotinamide, a form of vitamin B3

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