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while previously seen as tumor-suppressive, recent studies link its upregulation to enhanced cancer cell migration and invasion

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At the same time, compounds with this functional group improved the central nervous system bioavailability, suggesting that further fluorination of Tb MetRS inhibitors provided a new idea for the treatment of human African trypanosomiasis

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Besides PHD, ROS can also inhibit the activity of Jumonji domain-containing histone demethylase (JMJD), a family of Fe 2+ -dependent 2-OG oxygenases essential for epigenetic reprogramming in macrophages through histone demethylation