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This provides a new direction for the future development of clinical treatments for MTrPs

This phenomenon can be prevented by the specific MCU inhibitor Ru360 (Calvo-Rodriguez et al., 2020)

Similarly, the first in vivo imaging studies in humans, confirmed an increase in OS and a simultaneous decrease in GSH levels in the motor cortex of patients with ALS (with an age of 65.2 9.4 years, and a mean disease duration of 25.8 17.1 months) compared to the controls [106, 107]

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TGF-1, Transforming growth factor-1

RhoA activation, EAAT3/DAT/NET internalization and CaMKII activation all require calcium, indicating that mobilization of calcium is upstream of all other events and suggesting that calcium modulates RhoA activation during the intracellular signaling events activated by AMPH (Fig