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During stressful conditions, such as MTX-induced oxidative damage, unresolved ER stress leads to the accumulation of unfolded proteins promoting apoptosis (Teske et al., 2011)

Only 78 (16%) of patients were previously aware of their diagnosis of HH (Table 1)

In accordance with these data, we identify non-NE SCLC to be exquisitely ferroptosis sensitive and to express EMT signature genes, such as vimentin

Structural and functional insights into the interaction between Ku70/80 and Pol X family polymerases in NHEJ

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These latter findings reduced enthusiasm for antioxidant-based treatments of A-T despite the apparent benefits of NAC or nitroxides