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10.1371/journal.pone.0112726 PLoS One

Phase 2A proof-of-concept double-blind, randomized, placebo-controlled trial of nicotinamide in early Alzheimer disease

Specifically, magnesium is required by several enzymes involved in the citric acid cycle and electron transport chain---mitochondrial processes that help turn the carbohydrates, proteins, and fats consumed in our diet into ATP