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2025;64(6):e202418707

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In the sections below, we discuss the evidence of efficacy for current clinical use of these regenerative therapies in EDS

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PMID: 127 TangJJiHRenJLiMZhengNWuL

Several examples have also now emerged suggesting the GH/IGF-1 signaling pathway is relevant to human aging 12 , including the discovery of functional mutations in the IGF-1R gene in individuals with exceptional longevity, resulting in relative IGF-1 resistance 13,14 , and in subjects lacking functional GH receptors (Laron dwarfs) 15