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Laboratory studies show that curcumin is incorporated into Reed-Sternberg cells and then inhibits both NF-B and STAT3 activation, leading to lymphoma cell death and a significant 80-97% reduction in Reed-Sternberg cell viability (Mackenzie 2008)

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1 g of high-quality RNA is retrotranscribed with iScript advanced (BioRad) in a final volume of 20 lComplete reaction mix is incubated in a thermal cycler (Eppendorf) at 42 C

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Each escalation step requires a minimum of four weeks before moving up