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In addition to their detrimental effect on texture, catheptic enzymes induce intentional autolytic changes in fermented fish products

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For instance, SIRT7 has been identified as a key player in the pathogenesis of immune-mediated intestinal inflammation, specifically in inflammatory bowel disease (IBD)

Critically, these effects were absent in 3-AR knockout mice, indicating that an intact 3-AR pathway is required for the lipolytic activity

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As a result, the effectors are influenced by signals from the ligation of the target molecule by the Fab-binding site of the antibody and the simultaneous engagement of the Fc domain of the IgG by the different FcRs