Full disclaimer 1.AOD-9604 is a 16-amino acid peptide fragment derived from human growth hormone (hGH residues 177-191) with added tyrosine, developed by Metabolic Pharmaceuticals for obesity treatment 2.Proposed mechanism: selective stimulation of lipolysis (fat breakdown) and inhibition of lipogenesis (fat formation) without growth hormone-like effects on IGF-1 or blood glucose 3.Failed Phase 2b clinical trial for obesity (2007)did not demonstrate statistically significant weight loss versus placebo, terminating clinical development for this indication 4.Received FDA "Generally Recognized as Safe" (GRAS) designation in 2023 as a food substance, but this is NOT a drug approval and does not establish efficacy for weight loss 5.Regulatory status: not FDA-approved as a drug, prohibited by WADA, and insufficient evidence for weight loss efficacy
This is why oral BPC-157 is commonly used in gut-focused protocols
This peptide might target the beta-3 adrenergic receptors (ADRB3), which may potentially induce weight loss downstream
However, studies assessing bioavailability of B12 from specific food sources in healthy participants have shown that absorption varies depending on both the specific food product and the magnitude of the dose, ranging from 36%24% for egg products (dose 0.30.94mg, respectively), 83%52% for lean meat (dose 0.545.11mg, respectively), 42%30% for fish (dose 2.113.1mg, respectively) and 49%4.5% for liver products (dose 0.538mg, respectively) (Doets et al., 2013)
Vitamin B12 supplements Cobalamin compounds such as cyanocobalamin and hydroxycobalamin are commonly given as supplements
This means that although my B12 level was high in my blood, it was staying in my blood: useless to me
