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ED largely contributed to section BloodBrain Barrier, BloodCerebrospinal Fluid Barrier, and Neurovascular Unit and prepared all the figures

10.3390/ijms25010484 261 MizunoM.ItoK.NakaiH.KatoH.KamiuraS.UshijimaK.et al (2023)

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[1] The resulting GH surge drives hepatic IGF-1 synthesis over roughly 90 to 120 minutes post-injection

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These are uncommon at standard therapeutic doses and typically indicate the dose needs adjustment