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Therefore, its production may be decreased under specific different pathophysiological situations and metabolic conditions (67)

IP3 may trigger the release of calcium ions (Ca2+) from intracellular stores, while DAG may activate protein kinase C (PKC)

J Neurosurg 1999

Incorporating ferroptosis agonists with chemotherapy drugs could emerge as an innovative approach to cancer therapy ( Ferroptosis-associated antitumor combination therapy There have been limited studies on combining ferroptosis inducers with other anti-tumor therapies for clinical treatment, with many investigations still in the experimental phase