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The roles of tertiary lymphoid structures in chronic diseases

The knockdown or knockout efficiency was verified by western blotting

Toxicity and therapeutic efficacy of such agents can be determined by standard pharmaceutical procedures in cell cultures or experimental animals, e.g., for determining the LD50 (the dose lethal to 50% of the population) and the ED50 (the dose therapeutically effective in 50% of the population)

A cell migration assay was performed using a Boyden chamber set (Neuro Probe, Inc.), according to the manufacturer's instructions

Qadir T, Amin A, Sharma PK et al (2022) A review on medicinally important heterocyclic compounds

In general, studies implied that the specific role of eosinophils in DILI depends on the type of drugs, and there is more evidence supporting protective mechanism for APAP hepatotoxicity