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In addition, examination of the mice reveals that the patients neutrophils are invading the cell bodies of the neurons just outside the spinal cord

Due to the multiple effects of SARS-CoV-2 that alter cellular metabolic and oxidative states, there are multiple directions to deplete NAD+, loss of cellular ATP and reduced Poly-ADP-ribose polymerase (PARP) activity, each of which have cytotoxic effects of their own [69]