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Recent Progress in Ferroptosis inducers for Cancer therapy

10.2217/nnm.15.9 43 Del MondoA.SmerilliA.SanE.SansoneC.BrunetC

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The compound is not listed as a scheduled controlled substance under the international drug-control conventions or under the major national scheduling systems

GSK3B is known for its role as a negative regulator for transcription factors, microtubules, and Wnt signalling, as well as in the hormonal control of glucose homeostasis as well as neurological disorders 26,27 This crystal structure reveals that VAL 135 and ASP 133 are important, and interactions with these amino acids may enhance the inhibitors activity (Fig