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NPY Neuron and IGF-1/Akt Pathway Activation Chronic systemic administration of GHRP-6 to normal adult rats increases IGF-1 mRNA and phosphorylated Akt (pAkt) levels in various brain regions including the hypothalamus with GHRP-6 specifically stimulating NPY and IGF-1 mRNA synthesis and activating Akt in neuropeptide Y neurons of the arcuate nucleus, suggesting that some of GHRP-6s effects involve stimulation of local IGF-1 production and Akt activation in NPY neurons

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