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(2017) suggested that hydrogen peroxide-inducible clone-5 (Hic-5) may be crucial for c-Met signaling pathways and HCC metastasis because it mediates HGF-induced reactive oxygen species (ROS)-JNK-signaling pathways in HCC (Wu et al., 2015) and may be also a specific and safe target for treating HCC patients

Measurement of GSH and GSSG Raji cells were seeded in a 6-well plate

Acknowledgments This work was supported in part by the Japan Study Group of NAFLD (JSG-NAFLD, Kyoto, Japan)

Of note, GSTO1 was identified as one of the cellular targets of locostatin, an oxazolidinone-based cell migration inhibitor, although its role in cell migration has not been well characterized 42

Possible confounding factors in patients include co-existing pathologies and treatments, lack of selection of treatments according to ROS levels, among others

CD8 + T cells, the primary immune effectors, exert substantial influence on HCC progression by participating in the clearance of infected and malignant cells