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Importantly, the autophagy activator rapamycin mitigated the reduction of CD133 + cells caused by CCND1 silencing, thereby confirming that LCSC development was hindered by autophagy inhibition [281]

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Wei and colleagues further investigated the critical mechanism of SHMT2 in CRC carcinogenesis

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Long-chain PUFAs are incorporated into membrane phospholipids of immune cells, where they modulate cell signaling of immune and inflammatory responses, such as phagocytosis and T-cell signaling