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The above phenomenon can be explained by the fact that the down-regulation of MITF expression will cause the down-regulation of TYR, TRP-1 and TRP-2, thereby inhibiting the synthesis of melanin, so the lower MITF expression will cause white plaques in patients with vitiligo

doi: 10.1016/S0140-6736(21)00184-7 8 ShiLZWangRHuangGVogelPNealeGGreenDRet al

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On top of enzymatic activities, transcriptomic analysis on the expression levels of GSH and PCs biosynthesis gene, which include II-ECS, IIGS, IIPCS , were found to be upregulated after 24-h treatment of GSH against Pb induced stress on leaves of the plant known as Iris lactea var

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