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In addition, variations in CSF collection time, storage temperature, and sample processing protocols may influence lactate measurements (Manyevitch et al., 2018)

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The pathogenic roles of LMNA (E358K) and LMNA (R453W) were previously reported to cause muscular laminopathy including CMD, EDMD, and EDMD2, our results confirm the pathological roles of LMNA (E358K) and LMNA (R453W) variants and suggest that the novel variants LMNA (L35P) and LMNA (A539V) may also have pathogenic implications

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