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& Schmid, R

These symptoms most often include: Paresthesia: Numbness, itching, burning, or tingling in the limbs or other parts of the body Ataxia: impaired coordination, balance, and speech Myelopathy: pain in the neck or back and tingling, numbness, or weakness in the limbs The occurrence of these conditions in people with vitamin B12 deficiency is due to the role of vitamin B12 in preventing nerve damage and ensuring efficient transmission of nerve impulses

Oxidative stress affects all aspects, such as inflammation, ED, neuroinflammation, disruption of neurotransmitter secretion, and coagulopathy development, which are responsible for the induction of persistent LC symptoms

10.1016/j.biomaterials.2009.02.043 117 TsumanumaY.IwataT.WashioK.YoshidaT.YamadaA.TakagiR.et al (2011)

doi:10.1242/jcs.237453 61

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