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this link is attributable to the detrimental effect of homocysteine on the endothelial cells that line the inside of blood vessels (van Dijk 2013

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Most evidence comes from animal models and in vitro studies

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Targets of the master regulator of biofilm formation in Bacillus subtilis

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PMID: 41973539 J VirolThe neddylation of the RNA-dependent RNA polymerase 3D of Coxsackievirus B3 promotes viral replication

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IGF-1R inhibition potentiates cytotoxic effects of chemotherapeutic agents in early stages of chemoresistant ovarian cancer cells

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Interestingly, this effect of male sex in hastening the onset of SP-MS and disability accrual has not been observed in more recent studies where a higher proportion of MS patients are receiving high-efficacy disease modifying therapies (30, 31), suggesting that the autoimmune inflammation may be a factor in the effect of male sex on progression

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