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For in vivo studies, a minimum of five mice per group was selected, which has been shown to be sufficient to detect biologically and statistically significant differences in similar experiments

Therefore, most of the data analysis below is based on ISCID spectra

This paradigm has changed our way of thinking in defining predictive biomarkers for antiangiogenic therapy

Enhancing GSH, mainly through NAC, GSH precursors or pro-GSH compound administration, becomes a potential treatment option for SARS-CoV-2 infection and COVID-19 disease by reducing oxidative stress and cytokine expression especially in diabetic patients at risk of more severe disease (Singh et al., 2022)

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