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have shown that human umbilical vein endothelial cells isolated from healthy newborns with a strong family history of T2DM exhibit abnormal intracellular synthesis of NO and impaired expression of the eNOS, GLUT1 and p53 genes, which are all associated with NO synthesis (Alvarado-Vsquez et al., 2007), the influence of superoxide NADPH oxidase (Griendling et al., 1)

PMID 25175865

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