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In the Trx superfamily, the number of hydrogen bonds formed by the Cys 1 of conserved Cys 1 X 1 X 2 Cys 2 motif was found to directly affect p K a

The impact of hypoxia on cytosolic NADP redox dynamics had remained less clear, since lack of oxygen as an electron sink causes metabolic reduction, but also boosts H 2 O 2 production and glutathione oxidation in different phases of the hypoxic episode [37]

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Parameters of network topology in these inferred pathways were calculated as markers of essential function

In this context, the small molecule erastin was reported to target and inhibit system x c , leading to cysteine starvation, glutathione depletion and consequently ferroptotic cell death