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I just want to first give the Chair of Rev and Tax an opportunity to make some comments if you have any, and then we'll

By using machine learning algorithms, we analyzed the 15 genes with LASSO logistic regression and SVM-RFE analysis, and five hub genes were identified to be significantly associated with ferroptosis, such as HIF1A , ACSL1 , CD82 , PEX2 and TFAP2A

that AFB1, as the parent compound, inhibited rat liver mitochondrial electron transport at the antimycin A-sensitive site (10) and postulated subsequently (5) that the enhanced liver cell necrosis and acute toxicity observed in the low-protein animals could be due to the low rate of metabolism and clearance of AFB1 with a consequent effect on mitochondrial respiration

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doi: 10.1111/dom.14572 24 Common Terminology Criteria for Adverse Events (CTCAE) v6.0 (MedDRA 28.0) (Bethesda, MD, USA: National Cancer Institute, National Institutes of Health)