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Guanosine prevents oxidative damage and glutamate uptake impairment induced by oxygen/glucose deprivation in cortical astrocyte cultures: involvement of A 1 and A 2A adenosine receptors and PI3K, MEK, and PKC pathways

RGCs are particularly vulnerable to metabolic insults and rely on mitochondrial oxidative phosphorylation for their high energy demands [320]

In 2003, Marnewick et al

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Exposure assessments, metabolic phenotyping, liver mRNA and histological analysis were conducted

Experimental evidence and clinical data suggest that ROS disrupts the BBB by degrading the TJs (Sandoval and Witt, 2008)