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Hypertension has been shown to be closely associated with an increase in free radicals, which counteracts normal endothelial performance ( 2 Role of a healthy endothelium in the regulation of blood pressure 2.1 The endothelial cell layer While until the early 1980s it was believed that the endothelium had a solely passive role in organizing the vascular envelope and managing the selective passage of water and electrolytes alone, it is now known that this tissue performs numerous other vital functions