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How long this phase lasts depends on how bad the deficiency is and how well the patient responds

10 Eight patients were randomized to receive Group A: kojic acid 1% cream, Group B: kojic acid 1% and hydroquinone 2% cream, Group C: KA 1% and betamethasone valerate (BV) 0.1% cream or Group D: KA 1%, HQ 2%, BV 0.1% cream for a 12-week period and compared every 12 weeks using MASI

That is what supervised clinical care provides and what a direct-to-consumer research-powder model cannot

Their combined action is important for protecting against oxidative damage