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Prolactin Regulates Kisspeptin Neurons in the Arcuate Nucleus to Suppress LH Secretion in Female Rats

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further revealed that functional impairment of the de novo pathway induces premature ovarian ageing: NAD + deficiency triggers ATP synthesis deficiency and ROS overaccumulation by inhibiting OXPHOS complex activity, which in turn induces granulocyte cell cycle arrest (G1/S phase) and mitochondria-dependent apoptotic pathway activation

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