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The immunogenicity of the RBD may be enhanced by presenting multiple copies of the RBD on a single particle to B cells, allowing multiple antigen-BCR engagements

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Given that cancer cell evolution involves the accumulation of genomic mutations, it is plausible to hypothesize that mutations in V-ATPase genes (and other genes such as KRAS ) benefit cancer cells by activating autophagy flux even in nutrient-rich environments to promote cell survival as a universal strategy 53