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If the dose threshold is reached at the beginning of the specified irradiation, then the subsequent responses are dose-independent (within a certain range)

Likewise, in addition to the mentioned Parkinsons disease models [198,199,200], these were induced by various central causes (e.g., spinal cord compression [170,230], stroke [145], traumatic brain injury [231], neurotoxin cuprizone that mimics multiple sclerosis in rats [232], neuroleptics [199,200], amphetamine [200,233], alcohol acute and chronic intoxication [234], serotonin syndrome [235], and NO-system blockade [200])

Acknowledgements This work was supported by the National Natural Science Foundation of China (52303085), the Science and Technology Development Program of Jilin Province (Grant Number SKL202302001), and a Special Project from MOST of China

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Figure 1 S-glutathionylation of many regulatory proteins (Pompella et al., E , directly affects the redox state and function of redox-sensitive regulatory proteins