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Stroeve, J

In medicine, tyrosinase is a key therapeutic target for treating a range of skin pigmentation disorders, including vitiligo 17 , hyperpigmentary 18,19,20,21 , and melanoma 22

10.3867/j.issn.1000-3002.2021.10.051 75 SunX.CuiX.ChenX.JiangX

Four trials were not blinded [13, 21, 22, 25], and two were only single blinded [18, 20]

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However, although our genetically engineered mouse model of RMC reproduces the aggressive and metastatic phenotypes observed clinically, there is no perfect equivalence between mouse models and human diseases, and thus, caution must be exercised when extrapolating these findings to the clinic