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Double-strand breaks DNA double-strand breaks (DSBs) are common and significantly impactful forms of DNA damage that typically occur when cells are exposed to ionizing radiation or during replication

No tolerance development appears to occur, unlike many pharmaceutical compounds

Curr Opin Organ Transplant

Electrolyte disturbances are well-recognised triggers for muscle cramps

Accumulating evidence suggests that inhibitors targeting epigenetic modifiers in combination with chemotherapeutic drugs help to re-sensitize chemoresistant cells [177, 188]

MTs, which are highly expressed in the nucleus during oxidative stress, act as both zinc reservoirs and redox buffers 42