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Isolation Screening and identification of actinobacteria with uricase activity: statistical optimization of fermentation conditions for improved production of uricase by Streptomyces rochei NEAE25

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This structure, being non-expandable and tightly associated with the plasma membrane, enables cells to resist the osmotic forces that would otherwise cause swelling and eventually lysis

Furthermore, the disrupted basement membrane serves as a direct migratory pathway for inflammatory cell infiltration, thereby exacerbating the inflammatory response within the brain parenchyma (156)

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