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It will be interesting to assess whether silencing the UCEs in these models can accelerate HCC development as in the sgAxin1 model

Similar patterns have been found in oral cancer and in patients receiving immunotherapy, where elevated B12 has been associated with poorer outcomes

doi: 10.1186/s12877-020-1472-9, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 543

Together, these pathways enhance dendritic cell activation, tumor antigen cross-presentation, and T-cell responses, and promote tumor microenvironment (TME) reprogramming and tertiary lymphoid structure (TLS) formation, establishing durable antitumor immunity