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Some of them include:

Although the levels of demethylation during the pre-implantation period are significant, a portion of DNA methylation will be kept during the reprogramming after fertilization, including the imprinted genes, which represent an inheritance from the paternal environment to the offspring phenotype (Jiang et al., 2018)

Although description of gonorrhea-like symptoms dates back to ancient civilizations like the Romans, Jews, and Arabs, genomic analysis suggests that the modern gonococcal population originated much more recently, possibly in the 16 th century, and was subsequently spread globally (Golparian et al., 2020)

These seemingly paradoxical effects may be one explanation for why patients with G6PD-d display increased susceptibility to infection indicative of an impaired immune response, while also displaying increased autoimmunity and inflammation indicative of an overactive immune system 13