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30 days (reconstituted) Mechanism Classification Primary Mechanism: NNMT (Nicotinamide N-methyltransferase) Inhibitor Target Enzyme: Nicotinamide N-methyltransferase Cellular Effect: Increases intracellular NAD+ and SAM levels Metabolic Pathway: NAD+ salvage pathway modulation Selectivity: Highly selective for NNMT (no cross-reactivity with related enzymes) Pharmacological Properties Route of Administration: Subcutaneous injection Bioavailability: High (subcutaneous)

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Eur J Endocrinol (1997) 137(5):4829.10.1530/eje.0.1370482 55 SpadaAArosioMBochicchioDBazzoniNVallarLBassettiMet alClinical, biochemical and morphological correlates in patients bearing growth hormone secreting tumors with or without constitutively active adenylyl cyclase

Semin Cell Dev Biol 20: 211218, 2009

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