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2015;99(Pt A):616

[DOI] [PubMed] [Google Scholar] 63.Mittal D, Gubin MM, Schreiber RD, Smyth MJ

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Furthermore, Endo-Exos exert a dual destructive effect in endothelial injury: they not only serve as carriers to synergistically transport matrix metalloproteinases (such as MMP-2 and MMP-9), directly enzymatically degrading vascular basement membrane components (90), but also target and inhibit mTOR kinase via the pathogenic miR-99a/b they are enriched with, driving sustained inflammatory responses during sepsis (91)

Winkler A., TU Mnchen, Department of Neurology

Abbreviations ALA: Alpha-lipoic acid (-lipoic acid) APO: Apocynin CAT: Catalase GPx: Glutathione peroxidase GR: Glutathione reductase GSH: Reduced glutathione GSHt: Total glutathione GSSG: Glutathione disulfide HFD: High-fat diet LFD: Low-fat diet OS: Oxidative stress OVA: Ovalbumin P: Probiotic ROS: Reactive oxygen species SFD: Standard fat diet SOD: Superoxide dismutase References Maniscalco M, Paris D, Melck DJ, DAmato M, Zedda A, Sofia M, Stellato C, Motta AJ