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Indeed targeting host-specific pathways could have devastating effects on the host as seen in the first phase 1 clinical trial of an agonistic anti-CD28 monoclonal antibody, which led to an incapacitating cytokine storm in the volunteers ( HDT encompass a continually growing arsenal of agents, which includes repurposed drugs, small molecules, synthetic nucleic acids, biologics, cytokines, cellular therapy, recombinant proteins and micronutrients ( 2 Early intervention using HDT to treat infectious disease The earliest point to target the host upon pathogen infection is to block or inhibit cellular entry thus rendering the host cell non-permissive ( Figure 1A )

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