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This is a critical step as the S-isomer is required for producing L-carnitine

10.1161/CIRCRESAHA.120.317933 24 DoiR.MasuyamaT.YamamotoK.DoiY.ManoT.SakataY.et al (2000)

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In addition, andrographolide has been found to decrease inflammatory cytokines in colonic epithelial cells by downregulating the CPT-11-induced cGAS-STING signaling pathway [51]