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This autonomic disturbance occurs relatively early in the disease course, affecting approximately 11.7% of patients at enrollment in clinical studiesexceeding the prevalence of diarrhea (2.4%) or unintentional weight loss (3.1%)

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stimulate dendritogenesis, dendrite spine formation, dendritic arborization, and synaptogenesis

Excess vitamin A appears to interfere with vitamin K absorption, whereas vitamin E may inhibit vitamin K-dependent carboxylase activity and interfere with the coagulation cascade (129)