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Description

Skin flushing: Temporary warmth or redness, particularly facial

NO binds to the reactive oxygen metabolites and generate peroxynitrite and leads to instigate lipid peroxidation which acts as a cytotoxic (damage cell membrane)

N-acetyl cysteine (NAC) is hydrophilic

Wasserman, R

Among them, compound 8u becomes the most effective xanthine oxidase inhibitor, with an IC50 value of 0.0288 mM, which is equivalent to febuxostat (IC50 0.0236 mM) (Zhang et al., 2019)