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Berberine is a dopamine D1- and D2-like receptor antagonist and ameliorates experimentally induced colitis by suppressing innate and adaptive immune responses

Upon activation by PAMPs or DAMPs, NLRP3 recruits and activates procaspase-1, which is then cleaved into caspase-1

In infancy, new strains outcompete old ones, and there is a rapid increase in diversity of the early microbiota that is somewhat unstable

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In the IBD model, the sphingosine-1-phosphate receptor 2 (S1PR2)/RhoA/ROCK1 pathway modulates ER stress, affecting vascular endothelial barrier function and classically activated macrophages (M1) macrophage polarization, further promoting intestinal inflammation [87]