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Research demonstrates that Dihexa induces hippocampal spinogenesis with potency comparable to HGF itself, significantly increasing the number of dendritic spines per unit length of dendrite in both dissociated neuronal cultures and organotypic hippocampal slice preparations

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Patients suffering from temporal lobe epilepsy, with sclerotic astrocytes and neuronal loss, often display a combination of highly elevated extracellular glutamate concentrations, also interictally, interictal hypometabolism, reduced glutamine synthetase activity and greatly reduced glutamine formation from glutamate (Petroff et al., acute intrastriatal administration of MSO decreases the extracellular glutamate concentration

This activation not only helps in neutralizing oxidative stress but also promotes cellular resilience against more significant stressors, thereby contributing to cancer chemoprevention and overall health maintenance

Available findings suggest that the initial dosage of allopurinol should be low, particularly in patients with renal impairment