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In the absence of ovarian dysfunction and insulin resistance in mice, high dietary fat intake increases the risk of endometriosis (69)

Collectively, the existing evidence indicates that multiple oncogenic signaling pathways, such as c-Myc, Kras, and HIF-1, directly regulate key processes in glutamine metabolism, thereby driving the tumor dependence on glutamine

Disturbed stress responses in women with polycystic ovary syndrome

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Tubular function GH-deficient children and adults display reduced sodium and total body water content and reduced extracellular and plasma volume compared to healthy subjects, while body fat mass is increased [137, 138]

The field requires urgent Phase I/II human trials before any clinical recommendations can be made