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How Does PT-141 work

oral Time (hours) Bioavailability (F) Can be used to define how well a drug is absorbed and reaches its site of action Usually determined by comparison of oral and IV absorption F= amount of drug absorbed in systemic circulatio n following oral administra tion amount of drug absorbed when the same dose is administer ed intravenou sly Measuring the drug in the plasma Half-life (T0.5 ) The time for the plasma drug concentration to fall to half its original value Clearance rate of eliminatio n clearance = plasma drug concentration Removal of drug from plasma First order kinetics Most drugs are eliminated with first order kinetics

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Additionally, one study indicated that the accumulation of autophagic substrates and impaired autophagic flux independently signify suppressed autophagy post-TBI (Sarkar et al., 2014)