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T-DXd, initially developed for HER2+ breast cancer, has shown efficacy in HR+ breast cancer with low HER2 expression ( Table 3 )

Distribution of vitamin d receptor and 1-hydroxylase in male mouse reproductive tract

The possible association of MEL with hepatic steatosis is based on historical observations that showed that pinealectomy increased serum glucose levels in laboratory animals, while administration of MEL corrected these abnormalities (100, 101)

We stratified discard grafts into overall discard, macro and micro steatosis 40% macro-steatosis were associated with inferior outcomes (HR: 1.5, 95%CI:1.2-1.7)

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