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Additional approaches, including siRNA-mediated NOX4 silencing and selective NOX1/4 inhibition, are being explored as potential therapeutic interventions [115, 116]

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2015) using small RNA sequencing analysis identified eight serum miRNAs (miR-122, miR-375, miR-423-5p, miR-30d-5p, miR-125b-5p, miR-4732-5p, miR-204-5p and miR-574-3p) which were increased more than twofold in APAP overdose samples ( n = 8)

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Samples were then washed and filtered through a Percoll gradient as previously described